DBCO-PEG4-VC-PAB-MMAE is an antibody-drug conjugate (ADC) complex composed of an ADC linker (DBCO-PEG4-VC-PAB) and the tubulin polymerization inhibitor MMAE. DBCO-PEG4-VC-PAB-MMAE is used for the synthesis of antibody-drug conjugates (ADCs). MMAE, a synthetic derivative of dolastatin 10, acts as a potent mitotic inhibitor by inhibiting tubulin polymerization[1].
References:
[1] Okeley NM, Miyamoto JB, Zhang X, et al. Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res. 2010 Feb 1;16(3):888-97.
DBCO-PEG4-VC-PAB-MMAE 是一种由ADC连接子(DBCO-PEG4-VC-PAB)和微管蛋白聚合抑制剂MMAE组成的抗体-药物偶联物(ADC)复合物。DBCO-PEG4-VC-PAB-MMAE可用于合成抗体-药物偶联物(ADCs)。MMAE是dolastatin10的合成衍生物，作为一种有效的有丝分裂抑制剂，通过抑制微管蛋白聚合发挥作用[1]。