D-Erythrose 4-phosphate sodium is the sodium phosphate salt of the monosaccharide erythrose, an intermediate in the pentose phosphate pathway and the Calvin cycle[1]. D-Erythrose 4-phosphate sodium can be used as a substrate to identify, differentiate and characterize various synthases that initiate the shikimate pathway in microorganisms and plants[2]. D-Erythrose 4-phosphate sodium can be used to identify, differentiate and characterize 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase[3]. Erythritol is converted to D-Erythrose 4-phosphate sodium through a series of reactions involving three isomerases that are homologous to the metal-dependent xylose isomerase-like superfamily, triose-P isomerase and ribose-P isomerase, respectively[4]. D-Erythrose 4-phosphate sodium can be used to measure the concentration of ribulose-5-phosphate (Ru-5-P) in cells[5]. D-Erythrose 4-phosphate sodium is a phosphoenolpyruvate analog and an inhibitor of chorionic villus mutase[6].
References:
[1] Robyt J F. General Occurrence of Carbohydrates[J]. Glycoscience: Chemistry and Chemical Biology I–III, 2001: 75-114.
[2] Ran N, Draths K M, Frost J W. Creation of a shikimate pathway variant[J]. Journal of the American Chemical Society, 2004, 126(22): 6856-6857.
[3] Ran N, Frost J W. Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase[J]. Journal of the American Chemical Society, 2007, 129(19): 6130-6139.
[4] Barbier T, Collard F, Zúñiga-Ripa A, et al. Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella[J]. Proceedings of the National Academy of Sciences, 2014, 111(50): 17815-17820.
[5] Liu R, Li W, Tao B, et al. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance[J]. Nature communications, 2019, 10(1): 991.
[6] Almeida A M, Marchiosi R, Abrahão J, et al. Revisiting the shikimate pathway and highlighting their enzyme inhibitors[J]. Phytochemistry Reviews, 2024, 23(2): 421-457.
D-Erythrose 4-phosphate sodium是单糖赤藓糖的磷酸钠盐，是磷酸戊糖途径和卡尔文循环的中间体[1]。D-Erythrose 4-phosphate sodium能够用作底物，用于识别、区分和表征微生物和植物中启动莽草酸途径的各种合成酶[2]。D-Erythrose 4-phosphate sodium能够用作鉴定、区分和表征2-酮-3-脱氧-6-磷酸半乳糖酸（KDPGal）醛缩酶[3]。赤藓糖醇通过一系列反应转化为D-Erythrose 4-phosphate sodium，这些反应涉及三种异构酶，这三种异构酶分别与金属依赖性木糖异构酶样超家族、丙糖-P异构酶和核糖-P异构酶同源[4]。D-Erythrose 4-phosphate sodium可用于细胞内核酮糖-5-磷酸（Ru-5-P）的浓度测量[5]。D-Erythrose 4-phosphate sodium是一种磷酸烯醇式丙酮酸类似物和绒毛膜酸变位酶的抑制剂[6]。