Cytembena is inhibitor for replicative DNA synthesis, purine synthesis and tetradrofolate formylase activity. Cytembena ameliorates ovarian or breast cancer, relieves the pain from skeletal metastases.
References:
[1]. Falkson HC, et al., Phase II trial of cytembena in patients with advanced ovarian and breast cancer. Cancer Treat Rep. 1976 Nov;60(11):1655-8.
[2]. Berger NA, et al., Description of a permeable eukaryotic cell system to study agents affecting DNA synthesis: demonstration that cytembena is a direct inhibitor of replicative DNA synthesis. J Natl Cancer Inst. 1977 Apr;58(4):1167-9.