Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities[1][2][3].
Cyclocurcumin (10-40 μM; 18 h) 导致 LPS 刺激的人巨噬细胞中 TNF-α 释放呈剂量依赖性显著抑制[1]。
Cyclocurcumin (5-25 μM) 对新分离大鼠主动脉环苯肾上腺素 诱导的血管收缩呈浓度依赖性 (IC50=14.9±1.0 μM)[2]。
Cyclocurcumin (5-25 μM; 30 min) 以剂量依赖的方式抑制细胞内钙的内流。Cyclocurcumin 以浓度依赖的方式抑制 l 型钙通道介导的血管收缩。Cyclocurcumin 的抗收缩作用是可逆的[2]。
Cyclocurcumin 具有很强的清除 ˙OH 和 ˙OOH 自由基的活性，其 4 ' -OH 酚自由基通过水中和生理环境中的原子转移机制优先清除 ˙OH 和 ˙OOH 自由基[3]。
[1]. Fu M, et al. Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. Int J Mol Med. 2017 May;39(5):1164-1172.
[2]. Kim K, et al. Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric). J Nat Prod. 2017 Jan 27;80(1):196-200.
[3]. Li Y, et al. Antioxidant properties and free radical scavenging mechanisms of cyclocurcumin. New Journal of Chemistry, 2018, 42(15): 12698-12705.