CY5-N3 is a functional fluorescent probe that combines the Cyanine5 dye with an azido group (ex/em=646/662nm). CY5-N3 can specifically and covalently link to alkyne-bearing compounds via a click chemistry reaction, enabling efficient fluorescent labeling of biomolecules. CY5-N3 is used in biological imaging, molecular labeling and tracking, drug screening and development, and related fields[1-4].
References:
[1] Palsuledesai CC, Ochocki JD, Markowski TW, et al. A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins. Mol Biosyst. 2014 May;10(5):1094-103.
[2] Gao Z, Zhang E, Zhao H, et al. Bacteria-Mediated Intracellular Click Reaction for Drug Enrichment and Selective Apoptosis of Drug-Resistant Tumor Cells. ACS Appl Mater Interfaces. 2022 Mar 16;14(10):12106-12115.
[3] Sundin C, Zetterström CE, Vo DD, et al. Exploring resveratrol dimers as virulence blocking agents - Attenuation of type III secretion in Yersinia pseudotuberculosis and Pseudomonas aeruginosa. Sci Rep. 2020 Feb 7;10(1):2103.
[4] Lam YY, Tan A, Nowell CJ, et al. Systematic Investigation of Metabolic Oligosaccharide Engineering Efficiency in Intestinal Cells Using a Dibenzocyclooctyne-Monosaccharide Conjugate. Chembiochem. 2023 Jun 15;24(12):e202300144.
CY5-N3是一种结合了Cyanine5荧光染料与叠氮基团的功能性荧光探针（ex/em=646/662nm）。CY5-N3可通过点击化学反应与炔基化合物特异性共价连接，实现生物分子的高效荧光标记。CY5-N3可用于生物成像、分子标记与追踪以及药物筛选与研发等领域[1-4]。