CVT-11127 (FMK13918) is an inhibitor of stearoylCoA desaturase-1 (SCD1). CVT-11127 reduces lipid synthesis and impaires proliferation by blocking the progression of cell cycle through the G(1)/S boundary and by triggering programmed cell death.
CVT-11127, an SCD1 inhibitor, decreases expression of SCD1, prevents the growth of STK11/KEAP1 co-mutant cells and sensitizes those cells to ferroptosis induction.[2]
[1] Daniel Hess, et al. PLoS One. 2010 Jun 30;5(6):e11394. [2] Wohlhieter CA, et al. Cell Rep. 2020 Dec 1;33(9):108444.