Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmetlaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast Inhibited cell viability at 48 hr.
Crisnatol (25 mg/kg; p.o.; single dose) 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱[2]。
[1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20.
[2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46.
[3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.