Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol . Cortisol sulfate is a specific ligand for intracellular transcortin[1][2][3].
Cortisol sulfate (3 mg; i.m.; every other day; for 2-7 weeks) affects behavior through its direct action on the central nervous system[4].
[1]. C S Hall, et al. Simultaneous metabolism of cortisol sulfate and cortisol in normal human adults. J Clin Endocrinol Metab. 1970 Oct;31(4):439-44. [2]. S S Singer, et al. Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations. Endocrinology. 1976 Apr;98(4):963-74. [3]. T Hayashi, et al. Cortisol-21-sulfate (FS) is a specific ligand for intracellular transcortin: demonstration of three types of high affinity corticosteroid binders in bovine aortic cytosol by a combined use of FS and RU 28362. Endocrinology. 1990 Jan;126(1):307-16. [4]. S Miyabo, et al. Behavioral and other systemic effects of cortisol-21 sulfate. Horm Behav. 1972 Sep;3(3):227-36.