Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.
Corn oil-gavaged rats have ~25% lower MNCL incidence as well as longer MNCL latency and increase survival. Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals. Corn oil-gavaged rats, which receive 5 mL corn oil /kg body wt/day for 5 days/week, have a 3-fold increase in fat intake compared to nongavaged or water-gavaged control rats[1]. Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40u201350 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats result in a marked decrease in the growth rate of both tumors[2].
玉米油是从玉米胚芽中提取出来的，可以作为药物分子的载体，并具有抗肿瘤活性。
给老鼠灌注玉米油可以降低MNCL的发生率约25％，延长MNCL潜伏期并增加存活率。接受玉米油灌胃的老鼠血清中生长激素（GH）水平下降54％，将GH替换到通过渗透压微泵输注玉米油的老鼠体内会使原位MNCL细胞增殖速度达到与喝水控制组动物相同的水平。每周5天，每天给予5毫升/公斤体重的玉米油灌胃后，与未经过或仅喝水控制组老鼠相比，其脂肪摄入量增加了3倍[1]。在成年雄性野牛大鼠大腿注射肝癌7777或7800组织40-50毫克前和后微量注射玉米油可显着减缓两种肿瘤的生长速度[2]。
[1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9.
[2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.