Coenzyme Q10-d6 (CoQ10-d6) is intended for use as an internal standard for the quantification of CoQ10 by GC- or LC-MS. CoQ10 is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands.1 It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP.2 In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species.2 CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies, and other chronic diseases.3,4
1.Saini, R.Coenzyme Q10: The essential nutrientJ. Pharm. Bioallied Sci.3(3)466-467(2011) 2.Crane, F.L.Biochemical functions of coenzyme Q10J. Am. Coll. Nutr.20(6)591-598(2001) 3.Wyman, M., Leonard, M., and Morledge, T.Coenzyme Q10: A therapy for hypertension and statin-induced myalgia•Cleve. Clin. J. Med.77(7)435-442(2010) 4.Quinzii, C.M., and Hirano, M.Primary and secondary CoQ10 deficiencies in humansBioFactors37(5)361-365(2011)