Caspofungin-d4 (acetate) is intended for use as an internal standard for the quantification of caspofungin by GC- or LC-MS. Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall.1 It is effective against disseminated or invasive aspergillosis and candidiasis.2,3 Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml.4 It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.1,3,5
|1. Letscher-Bru, V., and Herbrecht, R. Caspofungin: The first representative of a new antifungal class. J. Antimicrob. Chemother. 51(3), 513-521 (2003).|2. Abruzzo, G.K., Flattery, A.M., Gill, C.J., et al. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob. Agents Chemother. 41(11), 2333-2338 (1997).|3. Deresinski, S.C., and Stevens, D.A. Caspofungin. Clin. Infect. Dis. 36(11), 1445-1457 (2003).|4. Pfaller, M.A., Boyken, L., Hollis, R.J., et al. In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: A head-to-head comparison using the CLSI M38-A2 broth microdilution method. J. Clin. Microbiol. 47(10), 3323-3325 (2009).|5. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005).