Cartap hydrochloride, an organonitrogen insecticide, can cause a marked irreversible Ca2+-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells.
Cartap hydrochloride (10-1000 μM; 24 hours) exerts a dose- and time-dependent cytotoxic effect in C2C12 cells. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells in a dose- and time-dependent manner[1].
References:
[1]. Jiunn-Wang Liao, et al. Cartap-induced cytotoxicity in mouse C2C12 myoblast cell line and the roles of calcium ion and oxidative stress on the toxic effects. Toxicology. 2006 Feb 15;219(1-3):73-84