Carbendazim is the degradation product and active ingredient of the carbamate fungicide benomyl.1,2 Carbendazim (100 ?M) disrupts the growth of S. cerevisiae by inhibiting microtubule polymerization.1 It impairs meiosis and steroidogenesis in an ex vivo rat model of seminiferous tubules and increases prostate weight in rats when administered at a dose of 100 mg/kg but does not affect other testosterone-dependent or estrogen-dependent tissues.3,4
1.Quinlan, R.A., Pogson, C.I., and Gull, K.The influence of the microtubule inhibitor, methyl benzimidazol-2-yl-carbamate (MBC) on nuclear division and the cell cycle in Saccharomyces cerevisiaeJ. Cell. Sci.46341-352(1980) 2.Chiba, M., and Veres, D.F.Fate of benomyl and its degradation compound methyl 2-benzimidazolecarbamate on apple foliageJ. Agric. Food Chem.29(3)588-590(1981) 3.Pisani, C., Voisin, S., Arafah, K., et al.Ex vivo assessment of testicular toxicity induced by carbendazim and iprodione, alone or in a mixtureALTEX33(4)393-413(2016) 4.Rama, E.M., Bortolan, S., Vieira, M.L., et al.Reproductive and possible hormonal effects of carbendazimRegul. Toxicol. Pharmacol.69(3)476-486(2014)