Calcium D-glucarate is the calcium salt form of D-glucaric acid.1 D-Glucaric acid is an end product of D-glucuronic acid metabolism in mammals that has also been found in fruits and vegetables and has anticancer activity.2 It is produced by the oxidation of D-glucuronic acid and is a precursor in the biosynthesis of the β-glucuronidase inhibitor D-glucaro-1,4-lactone in vivo.1 Dietary administration of calcium D-glucarate (10% w/w) reduces tumor growth in a rat model of mammary tumorigenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA).3 Urinary D-glucaric acid levels have been used as a marker for xenobiotic-induced phase II metabolism in patients with rheumatoid arthritis or individuals exposed to environmental toxicants.4,5
1.Walaszek, Z.Potential use of D-glucaric acid derivatives in cancer preventionCancer Lett.54(1-2)(1990) 2.ZÓ?taszek, R., Hanausek, M., Kiliańska, Z., et al.The biological role of D-glucaric acid and its derivatives: potential use in medicinePostepy. Hig. Med. Dosw. (Online)62451-462(2008) 3.Walaszek, Z., Hanausek-Walaszek, M., Minton, J.P., et al.Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesisCarcinogenesis7(9)1463-1466(1986) 4.Addyman, R., Beyeler, C., Astbury, C., et al.Urinary glucaric acid excretion in rheumatoid arthritis: influence of disease activity and disease modifying drugsAnn. Rheum. Dis.55(7)478-481(1996) 5.IdÉo, G., Bellati, G., Bellohuono, A., et al.Urinary D-glucaric acid excretion in the Seveso area, polluted by tetrachloro-dibenzo-p-dioxin (TCDD): five years of experienceEnviron. Health Perspect.60151-157(1976)