C24 Ceramide (d18:1/24:0) is a natural ceramide (Cer) with a long acyl chain of 24 carbon units[1]. C24 Ceramide (d18:1/24:0) is a sphingomyelin (SM) that can be used to form lipid membranes[2]. C24 Ceramide (d18:1/24:0) can induce time-dependent changes in membrane properties and promote strong changes in vesicle shape[3]. The production of C24 Ceramide (d18:1/24:0) can promote spontaneous neutrophil apoptosis[4]. C24 Ceramide (d18:1/24:0) can be used as an internal standard in liquid chromatography-mass spectrometry (LC-MS) to quantify ceramide from animal samples[5]. C24 Ceramide (d18:1/24:0) can be used as a potential biomarker to distinguish metabolically healthy obesity (MHO) from metabolically unhealthy obesity (MUO)[6].
References:
[1] Pullmannová P, Pavlíková L, Kováčik A, et al. Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains[J]. Biophysical chemistry, 2017, 224: 20-31.
[2] González-Ramírez E J, García-Arribas A B, Sot J, et al. C24: 0 and C24: 1 sphingolipids in cholesterol-containing, five-and six-component lipid membranes[J]. Scientific Reports, 2020, 10(1): 14085.
[3] Ventura A E, Varela A R P, Dingjan T, et al. Lipid domain formation and membrane shaping by C24-ceramide[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2020, 1862(10): 183400.
[4] Seumois G, Fillet M, Gillet L, et al. De novo C16-and C24-ceramide generation contributes to spontaneous neutrophil apoptosis[J]. Journal of Leucocyte Biology, 2007, 81(6): 1477-1486.
[5] Kauhanen D, Sysi-Aho M, Koistinen K M, et al. Development and validation of a high-throughput LC–MS/MS assay for routine measurement of molecular ceramides[J]. Analytical and bioanalytical chemistry, 2016, 408: 3475-3483.
[6] Yu B, Hu M, Jiang W, et al. Ceramide d18: 1/24: 1 as a potential biomarker to differentiate obesity subtypes with unfavorable health outcomes[J]. Lipids in Health and Disease, 2023, 22(1): 166.
C24 Ceramide (d18:1/24:0)是一种天然的神经酰胺（Cer），具有24个碳单位的长酰基链[1]。C24 Ceramide (d18:1/24:0)是一种鞘磷脂（SM），可用于构成脂质膜[2]。C24 Ceramide (d18:1/24:0)能够诱导膜特性的时间依赖性变化，促进囊泡形状的强烈变化[3]。C24 Ceramide (d18:1/24:0)的产生能够促进自发性中性粒细胞凋亡[4]。C24 Ceramide (d18:1/24:0)能够作为液相色谱-质谱法（LC-MS）中的内标物从动物样品中定量测定神经酰胺[5]。C24 Ceramide (d18:1/24:0)能够作为一种潜在的生物标志物来区分代谢健康肥胖（MHO）和代谢不健康肥胖（MUO）[6]。