Bupranolol is an antagonist of β-adrenergic receptors (β-ARs; Kis = 6-15 nM for β1- and β2-ARs).1 In vivo, bupranolol (10 ?mol/kg) reduces heart rate and diastolic blood pressure in pithed rats.2
1.Wellstein, A., Küppers, H., Pitschner, H.F., et al.Transdermal delivery of bupranolol: Pharmacodynamics and beta-adrenoceptor occupancyEur. J. Clin. Pharmacol.31(4)419-422(1986) 2.Malinowska, B., Kie?-Kononowicz, K., Flau, K., et al.Atypical cardiostimulant β-adrenoceptor in the rat heart: Stereoselective antagonism by bupranolol but lack of effect by some bupranolol analoguesBr. J. Pharmacol.139(8)1548-1554(2003)