GlpBio

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

目录号: GC73205纯度: >98.00%
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT（式V）是一种试剂-接头偶联物，由强效拓扑异构酶I抑制剂和接头组成，用于制备抗体-试剂偶联物（ADC）。
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
Cas No.: 2857037-70-6
规格价格库存数量操作
1 mg¥7,470.00现货
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make antibody agent conjugate (ADC).

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be conjugated to an anti-c-Met antibody to form an anti-c-Met topoisomerase 1 Inhibitorsantibody drug conjugate (ADC)[1].

References:
[1]. Phillips AC, et, al. Anti-c-met antibody drug conjugates. WO2022232834A1.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2857037-70-6
分子式
C36H38BrN5O9
分子量
764.62 g/mol
溶解性
DMSO : 100 mg/mL (130.78 mM; Need ultrasonic)
保存条件
-20°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol