Bisphenol A is a phenolic organic synthetic compound, which is used as a raw material for synthetic plastics (mainly certain polycarbonates and epoxy resins), and polysulfones [1]. Bisphenol A can be used in studies related to cancer, cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductive disorders [2].
In vitro, Bisphenol A (0-400μM, 24 hours) inhibited the proliferation of human colon cancer cells HCT116 and induced their apoptosis through the mitochondrial and MAPK/AKT pathways [3]. Bisphenol A (0.5-12.5μM, 5 days) dose-dependently inhibited the formation of TRAP-positive multinucleated cells induced by RANKL in bone marrow-derived macrophages (BMM) [4].
In vivo, Bisphenol A (200mg/kg/d; SC; 4 weeks) significantly reduced the weights of the testes, epididymis, prostate and seminal vesicles in Wistar rats, as well as the daily sperm production in the testes [5]. Bisphenol A (100µg/kg; twice a day for 8 days; SC) inhibited the basal insulin secretion in mice, reduced food intake, body temperature and activity ability of mice, and upregulated the expression of IRS-1 protein under basal conditions in skeletal muscle [6].
References:
[1] Rubin BS. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):27-34.
[2] Rochester J R. Bisphenol A and human health: a review of the literature[J]. Reproductive toxicology, 2013, 42: 132-155.
[3] Qu W, Zhao Z, Chen S, Zhang L, Wu D, Chen Z. Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways. Life Sci. 2018 Sep 1;208:167-174.
[4] Hwang JK, Min KH, Choi KH, Hwang YC, Jeong IK, Ahn KJ, Chung HY, Chang JS. Bisphenol A reduces differentiation and stimulates apoptosis of osteoclasts and osteoblasts. Life Sci. 2013 Sep 17;93(9-11):367-72.
[5] Takahashi O, Oishi S. Testicular toxicity of dietarily or parenterally administered bisphenol A in rats and mice. Food Chem Toxicol. 2003 Jul;41(7):1035-44.
[6] Batista T M, Alonso-Magdalena P, Vieira E, et al. Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice[J]. PloS one, 2012, 7(3): e33814.
Bisphenol A是一种酚类有机合成化合物，是合成塑料（主要是某些聚碳酸酯和环氧树脂）、聚砜的原料 [1]。Bisphenol A可用于癌症、心血管疾病、呼吸系统疾病、糖尿病、肾脏疾病、肥胖和生殖障碍的研究 [2]。
在体外，Bisphenol A（0-400μM；24h）能够通过线粒体和MAPK/AKT通路抑制人结肠癌细胞HCT116的增殖并诱导其凋亡 [3]。Bisphenol A（0.5-12.5μM；5 天）能够剂量依赖性抑制骨髓来源的巨噬细胞（BMM）中RANKL诱导的TRAP阳性多核细胞形成 [4]。
在体内，Bisphenol A（200mg/kg/d；SC；4 weeks）显著降低Wistar大鼠的睾丸、附睾、前列腺和精囊重量，以及睾丸每日精子产量 [5]。Bisphenol A（100µg/kg；twice a day for 8 days；SC）抑制了小鼠的基础胰岛素分泌，降低了小鼠食物摄入量、体温降低和活动能力，并且上调IRS-1蛋白在骨骼肌的基础条件下的表达 [6] 。