BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in DC patient induced pluripotent stem cells.[1]
[1] Neha Nagpal, et al. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8.
















