BAY-885 is an inhibitor of ERK5 (IC50 = 0.035 ?M).1 It inhibits ERK5-induced transcription in SN12C-MEF2 reporter cells (IC50 = 0.12 ?M).
1.Nguyen, D., Lemos, C., Wortmann, L., et al.Discovery and characterization of the potent and highly selective (piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro probe BAY-885 for the kinase ERK5J. Med. Chem.62(2)928-940(2019)