Antibacterial agent 131

Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production.

Antibacterial agent 131 (compound 4m) has antimicrobial activity with MIC₉₀ values of 9.81 μg/mL for Escherichia coli ATCC 35218, E. coli ATCC 25922, Staphylococcus aureus ATCC 6538, and methicillin-resistant S. aureus (MRSA), respectively^[1].
Antibacterial agent 131 has anti-candida effect with MIC₉₀ values of ≤0.06, 0.24, 1.95, and 1.95 μg/mL for Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 24433, and C. glabrata ATCC 90030, respectively^[1].
Antibacterial agent 131 (24 h) has low cytotoxicity with an IC₅₀ value of 34.51 μM in NIH/3T3 cells^[1].
Antibacterial agent 131 (0.06-3.91 μg/mL) inhibits DNA-Gyrase Enzyme against E. coli^[1].
Antibacterial agent 131 has antifungal activity via blocking ergosterol production^[1].

References:
[1]. Asaf Evrim Evren, et al. Investigation of Novel Quinoline-Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches. ACS Omega. 2022 Dec 29;8(1):1410-1429.