Alisol C monoacetate is a triterpenoid that has been found in Alisma orientale and has diverse biological activities.1,2,3,4 It is active against certain antibiotic-resistant strains of S. aureus, E. faecium, E. coli, and P. aeruginosa (MICs = 2.5-5 ?g/ml) but not against other antibiotic-resistant strains of S. aureus or E. coli (MICs = >256 ?g/ml).2,3 Alisol C monoacetate (1-10 ?M) inhibits osteoclast formation induced by calcitriol in a co-culture of primary rat osteoblasts and primary rat bone marrow cells.4 It reduces trabecular bone loss and serum levels of a variety of cytokines, including TNF-α, IL-6, and IL-1β, in an ovariectomized rat model of osteoporosis when administered at doses of 1 and 2 mg/kg. Alisol C monoacetate (10 and 50 mg/kg) also reduces ear edema in a mouse model of delayed-type hypersensitivity.1
1.Lee, J.H., Kwon, O.S., Jin, H.-G., et al.The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitisBiol. Pharm. Bull.35(9)1581-1587(2012) 2.Jin, H.-G., Jin, Q., Kim, A.R., et al.A new triterpenoid from Alisma orientale and their antibacterial effectArch. Pharm. Res.35(11)1919-1926(2012) 3.Li, C., Yan, W., Cui, E., et al.Anti-bacterial effect of phytoconstituents isolated from Alimatis rhizomaAppl. Biol. Chem.64(9)1-5(2021) 4.Jia, X., Zhu, H., Li, G., et al.Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibitionBiomed. Pharmacother.137111321(2021)