Albendazole sulfone-d3 is intended for use as an internal standard for the quantification of albendazole sulfone by GC- or LC-MS. Albendazole sulfone is an active metabolite of the benzimidazole anthelmintic albendazole .1,2 It inhibits spore formation of E. hellem, E. cuniculi, and E. intestinalis in vitro (IC90s = <0.0001, <0.001, and <0.1 µg/ml, respectively).2
1.BaliharovÁ, V., VelÍk, J., FimanovÁ, K., et al.Inhibitory effect of albendazole and its metabolites on cytochromes P450 activities in rat and mouflon in vitroPharmacol. Rep.5797-106(2005) 2.Ridoux, O., and Drancourt, M.In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfone metabolitesAntimicrob. Agents and Chemother.42(12)3301-3303(1998)