Aflatoxin M1-13C17 (AFM1-13C17) is intended for use as an internal standard for the quantification of AFM1 by GC- or LC-MS. AFM1 is an active metabolite of aflatoxin B1 .1 It induces hepatocyte hyperplasia and hepatocellular carcinoma tumor formation in rats when administered at a dose of 1 mg/animal. AFM1 (6 mg/kg) increases hepatic total lipid levels and inhibits hepatic mitochondrial and cytoplasmic protein synthesis in rats.2
1.Wogan, G.N., and Paglialunga, S.Carcinogenicity of synthetic aflatoxin M1 in ratsFood Cosmet. Toxicol.12(3)381-385(1974) 2.Pai, M.R., Bai, N.J., and Venkitasubramanian, T.A.Aflatoxin induced inhibition of protein synthesisToxicon16(3)283-287(1978)