Adrenomedullin (1-50), rat is a 50-amino acid polypeptide that induces selective arterial vasodilation by activating the calcitonin gene-related peptide 1 (CGRP1) receptor[1]. In vivo, Adrenomedullin (1-50), rat can regulate hypoxic pulmonary hypertension by promoting the production of nitric oxide (NO) and hydrogen sulfide (H2S) and reducing pulmonary vascular remodeling in hypoxic rats[2, 3].
In vivo, intrathecal administration of rat Adrenomedullin (1-50) (20μg) for 3 days in a rat model of mechanical pain induced mechanical allodynia, increased the expression levels of pERK and nNOS in the spinal dorsal horn, increased the expression levels of Iba1 and GFAP in the spinal cord, and upregulated TRPV1 expression in dorsal root ganglion (DRG) cultures[4].
References:
[1] Berthiaume N, Claing A, Cadieux A, et al. Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors in the double-perfused mesenteric bed of the rat[J]. Canadian journal of physiology and pharmacology, 1995, 73(7): 1080-1083.
[2] Vadivel A, Abozaid S, van Haaften T, et al. Adrenomedullin promotes lung angiogenesis, alveolar development, and repair[J]. American journal of respiratory cell and molecular biology, 2010, 43(2): 152-160.
[3] Matsui H, Shimosawa T, Itakura K, et al. Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia[J]. Circulation, 2004, 109(18): 2246-2251.
[4] Huang H, Wang M, Hong Y. Intrathecal administration of adrenomedullin induces mechanical allodynia and neurochemical changes in spinal cord and DRG[J]. Neuroscience Letters, 2019, 690: 196-201.
Adrenomedullin (1-50), rat是一种由50个氨基酸组成的多肽，能够通过激活降钙素基因相关肽1（CGRP1）受体诱导选择性动脉血管舒张[1]。Adrenomedullin (1-50), rat在体内能够调节低氧性肺动脉高压，通过促进一氧化氮（NO）和硫化氢（H2S）的生成，减轻缺氧大鼠的肺血管结构重塑[2, 3]。
在体内，Adrenomedullin (1-50), rat（20μg）通过鞘内注射给药处理机械性疼痛模型大鼠3天，诱导产生了机械性异常性疼痛，增加了脊髓背角中pERK和nNOS的表达水平，增加了脊髓中Iba1和GFAP的表达水平，提高了背根神经节（DRG）培养物中TRPV1的表达[4]。