Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture[1].
Adhesamine (20 μg/mL; 0-30 d) 促进小鼠原代培养海马神经元的附着并提高其存活率。Adhesamine 还诱导小鼠原代培养海马神经元神经突分支和快速分化[1]。
Adhesamine (20 μg/mL; 1 d, 3 d, 4 d) 细胞表面硫酸肝素诱导细胞粘附并激活 FAK 磷酸化。Adhesamine 还通过 MAPK 激活刺激神经突分化[1]。
[1]. Hoshino M, et al. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29;427(2):297-304.