Adenine-13C is the 13C labeled Adenine[1]. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[2][3][4].
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2]. ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from drogen cyanide. Arch Biochem Biops. 1961 Aug;94:217-27.
[3]. Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman 2000. Structure of DNA.
[4]. Reader V. The assay of vitamin B(4). Biochem J. 193024(6):1827-31.