ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone , a peptide hormone found in the brain that is involved in the biological stress response.1 ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM.2 It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 ?M.3 ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).4
1.Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al.Non-corticotropic ACTH peptides modulate nerve development and regenerationRev. Neurosci.4(4)321-363(1993) 2.Vatolin, S., Phillips, J.G., Jha, B.K., et al.Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myelomaCancer Res.76(11)3340-3350(2016) 3.Verma, P.S., Miller, R.L., Taylor, R.E., et al.Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptidesBiochem. Biophys. Res. Commun.104(4)1484-1488(1982) 4.Bayés, A., Rodríguez de la Vega, M., Vendrell, J., et al.Response of the digestive system of Helicoverpa zea to ingestion of potato carboxypeptidase inhibitor and characterization of an uninhibited carboxypeptidase BInsect Biochem. Mol. Biol.36(8)654-664(2006)