ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone , a peptide hormone found in the brain that is involved in the biological stress response.¹ An acetylated form of ACTH (1-13), α-melanocyte stimulating hormone (α-MSH), is formed in the intermediate lobe of the pituitary gland by cleavage of ACTH (1-39), as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.^1,2 ACTH (1-13) is an agonist of melanocortin receptor 3 (MC3R) and MC4R, inducing cAMP production in vitro with EC₅₀ values of 0.18 and 19 nM, respectively, which is similar in potency to that of α-MSH.³ It induces differentiation of melanocytes when used at concentrations ranging from 0.001 to 1,000 nM.⁴ ACTH (1-13) (40 and 400 pmol, i.c.v.) decreases food intake in broiler chicks.⁵