Aceclidine is an agonist of muscarinic receptors (EC50 = 1.8-17 ?M for human M2).1 It induces contraction of iris sphincter muscle, resulting in miosis.2,3 Aceclidine has applications in glaucoma therapy and in basic research regarding muscarinic receptor signaling.1,2,4
1.Griffin, M.T., Figueroa, K.W., Liller, S., et al.Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15J. Pharmacol. Exp. Ther.321(3)1193-1207(2007) 2.Ishikawa, H., Desantis, L., and Patil, P.N.Selectivity of muscarinic agonists including (+/-)-aceclidine andantimuscarinics on the human intraocular musclesJ. Ocul. Pharmacol. Ther.14(4)363-373(1998) 3.Smith, S.A., and Smith, S.E.Factors determining the potency of cholinomimetic miotic drugs and their effect upon the light reflex in manBr. J. Clin. Pharmac.6149-153(1978) 4.Shannon, H.E., Hart, J.C., Bymaster, F.P., et al.Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in ratsJ. Pharmacol. Exp. Ther.290(2)901-907(1999)