GlpBio

Acacetin

目录号: GN10812纯度: >99.50%同义词: 金合欢素; 5,7-Dihydroxy-4'-methoxyflavone
A flavonoid
Acacetin
Cas No.: 480-44-4
规格价格库存数量操作
1mg¥116.00现货
1
5mg¥231.00现货
1
10mg¥347.00现货
1
25mg¥595.00现货
1
50mg¥893.00现货
1
100mg¥1,338.00现货
1
500mg¥2,879.00现货
1
10mM (in 1mL DMSO)¥361.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly suppressed the photoreceptor collapse. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) inhibited the generation of the APP-CTF by affecting APP cleavage. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) prolongs lifespan of significantly in the dose dependent manner[1].

References:
[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127.
[2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
480-44-4
同义词
金合欢素; 5,7-Dihydroxy-4'-methoxyflavone
化学名
5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
SMILES
COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
分子式
C16H12O5
分子量
284.26 g/mol
溶解性
70mg/mL in DMSO (Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol