GlpBio

84-B10

目录号: GC68580纯度: >99.50%
84-B10 是一种 3-苯基戊二酸衍生物。84-B10 抑制 cisplatin 诱导的肾小管铁死亡。84-B10 减轻 cisplatin 诱导的线粒体损伤和氧化应激。84-B10 改善 cisplatin 诱导的急性肾损伤 (AKI)。
84-B10
Cas No.: 698346-43-9
规格价格库存数量操作
5mg¥1,080.00现货
1
10mg¥1,800.00现货
1
25mg¥3,510.00现货
1
50mg¥5,400.00现货
1
100mg¥8,100.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (Decreased the sCr and BUN levels of cisplatin-exposed mice.
Attenuated renal tubules morphological abnormalities in a dose-dependent manner.
Decreased NGAL and KIM-1 levels in a dose-dependent manner.
Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1.

[1]. Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
698346-43-9
分子式
C25H22F3NO5
分子量
473.44 g/mol
溶解性
DMSO : 100 mg/mL (211.22 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol