8(R),11(S)-DiHODE is a fungal oxylipin that has been found in Aspergillus.1,2 It is formed via isomerization of an 8(R)-HpODE intermediate during the oxidation of linoleic acid in several species of Aspergillus.
|1. JernerÉn, F., Garscha, U., Hoffmann, I., et al. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. Biochim. Biophys. Acta 1801(4), 503-507 (2010).|2. Garscha, U., JernerÉn, F., Chung, D., et al. Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism. J. Biol. Chem. 282(48), 34707-34718 (2007).