7-Ethoxycoumarin is a substrate for cytochrome P450 (CYP).1 It undergoes O-deethylation by various CYP isoforms, including CYP1A1, -1A2, and -2B in mice and CYP2E1 in humans. 7-Ethoxycoumarin has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea.2,3,4
1.Okamatsu, G., Komatsu, T., Kubota, A., et al.Identification and functional characterization of novel feline cytochrome P450 2AXenobiotica45(6)503-510(2015) 2.Kajbaf, M., Ricci, R., Zambon, S., et al.Contribution of rat intestinal metabolism to the xenobiotics clearanceEur. J. Drug Metab. Pharmacokinet.38(1)33-41(2013) 3.KÖlln, C., and Reichl, S.Cytochrome P450 activity in ex vivo cornea models and a human cornea constructJ. Pharm. Sci.105(7)2204-2212(2016)