Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.1,2,3
1.Zastawny, T.H., Altman, S.A., Randers-Eichhorn, L., et al.DNA base modifications and membrane damage in cultured mammalian cells treated with iron ionsFree Radic. Biol. Med.181013-1022(1995) 2.Spencer, J.P.E., Jenner, A., Chimel, K., et al.DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cellsFEBS Lett.374(2)233-236(1995) 3.Jaruga, P., Zastawny, T.H., Skokowski, J., et al.Oxidative DNA base damage and antioxidant enzyme activities in human lung cancerFEBS Lett.34159-64(1994)
















