Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.1,2 Recently, various DHA metabolites, including 7(R)-Maresin 1 and 10(S),17(S)-DiHDoHE , have been shown to block infiltration of neutrophils during an acute inflammatory response.3,4 4(S),11(R)-DiHDoHE is a dihydroxy-DHA derivative. The biological actions of this compound have not yet been determined.
|1. Su, H.-M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J. Nutr. Biochem. 21(5), 364-373 (2010).|2. Wu, T.C., and Chen, P.H. Health consequences of nutrition in childhood and early infancy. Pediatr. Neonatol. 50(4), 135-142 (2009).|3. Serhan, C.N., Yang, R., Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J. Exp. Med. 206(1), 15-23 (2009).|4. Serhan, C.N., Gotlinger, K., Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. J. Immunol. 176(3), 1848-1859 (2006).