GlpBio

4,5-Dimethoxycanthin-6-one

目录号: GC68544纯度: >98.00%
4,5-Dimethoxycanthin-6-one 是一种有效的、非竞争性的 CYP1A2 介导的 phenacetin O-deethylation 抑制剂，其 IC50 值为 1.7 μM, Ki 值为 2.6 μM。4,5-Dimethoxycanthin-6-one 为生物碱，从 Picrasma quassioides BENNET (Simaroubaceae) 中分离得到。
4,5-Dimethoxycanthin-6-one
Cas No.: 18110-87-7
规格价格库存数量操作
1mg¥810.00现货
1
5mg¥1,980.00现货
1
10mg¥3,420.00现货
1
10mM (in 1mL DMSO)¥2,493.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deetlation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].

4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deetlation with an IC50 value of 1.7μM and a Ki value of 2.6 μM[2].

[1]. Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents
[2]. Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
18110-87-7
分子式
C16H12N2O3
分子量
280.28 g/mol
溶解性
DMSO : 10 mg/mL (35.68 mM; Need ultrasonic)
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol