4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43. [1] It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively. [1] In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.[1]
Reference:
[1]. Slack, J.P., Brockhoff, A., Batram, C., et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 20(12), 1104-1109 (2010).