25-droxytacsterol3 is the metabolite of Vitamin D3 . 25-droxytacsterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-droxytacsterol3 activates vitamin D receptor (VDR) and aryl drocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1.
References:
[1]. Slominski AT, et al., Metabolic activation of tacsterol3 to biologically active droxyderivatives that act on VDR, AhR, LXRs, and PPARγ receptors. FASEB J. 2022 Aug;36(8):e22451.