2-Thiocytidine is a modified nucleobase found in bacterial and archaeal tRNA.1,2 2-Thiocytidine is also an intermediate in the synthesis of pyrimidine β-ribonucleosides and β-ribonucleotides.3
1.Shigi, N.Biosynthesis and functions of sulfur modifications in tRNAFront. Genet.567(2014) 2.?avu?i?, M., and Liu, Y.Biosynthesis of sulfur-containing tRNA modifications: A comparison of bacterial, archaeal, and eukaryotic pathwaysBiomolecules7(1)27(2017) 3.Xu, J., Tsanakopoulou, M., Magnani, C.J., et al.A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerizationNat. Chem.9(4)303-309(2017)