2’,3’-Dideoxyadenosine is prodrug form of the nucleoside reverse transcriptase inhibitor (NRTI) 2’,3’-dideoxyadenosine 5’-triphosphate .1 It inhibits HIV replication in HIV-infected MT-4 cells when used at concentrations of 5 and 125 ?M and protects ATH8 cells against the cytopathic effect of HIV (EC50 = 2.7 ?M).2
1.Schlienger, N., Lefebvre, I., Aubertin, A.-M., et al.Mononucleoside phosphorodithiolates as mononucleotide prodrugsEur. J. Med. Chem.227113914(2022) 2.Herdewijn, P., Blazarini, J., Clercq, E.D., et al.3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agentsJ. Med. Chem.30(8)1270-1278(1987)