GlpBio

2'2'-cGAMP (sodium salt)

目录号: GC42080纯度: >98.00%同义词: Adenosine-Guanosine 2’,2’-cyclic monophosphate, cGAMP(2’-5’), 2’,2’-Cyclic GMP-AMP
A synthetic dinucleotide
2'2'-cGAMP (sodium salt)
Cas No.: 1465774-27-9
规格价格库存数量操作
1mg¥10,996.00现货
1
500μg¥6,499.00现货
1
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文献被引

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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 µM, respectively). Despite weaker binding, 2'2'-cGAMP induces IFN-β production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1465774-27-9
同义词
Adenosine-Guanosine 2’,2’-cyclic monophosphate, cGAMP(2’-5’), 2’,2’-Cyclic GMP-AMP
SMILES
O=P(OC[C@](O[C@H]1N2C=NC3=C2NC(N)=NC3=O)([H])C(O)[C@@]1([H])O4)(O)O[C@]([C@H](N5C=NC6=C5N=CN=C6N)O7)([H])C(O)[C@@]7([H])COP4(O)=O.[Na+].[Na+]
分子式
C20H24N10O13P2•2Na
分子量
720.4 g/mol
溶解性
Water: soluble
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol