2-Phenylethanol is an important aromatic alcohol with a rose-like aroma [1].2-Phenylethanol has anti-tyrosinase and antibacterial activities [2]. 2-Phenylethanol is used in the food, flavor and cosmetic industries [3].
In F. graminearum, 2-Phenylethanol (0.6mg/mL, 1.2mg/mL, 2.4mg/mL; 14d) exhibited excellent inhibition of the mycelial growth of F. graminearum with the EC50 value at 0.328mg/mL [4]. In A. hydrophila, 2-Phenylethanol (1mg/mL; 24h) significantly inhibited A. hydrophila biofilm formation [5].
In C57BL/6 mice, inhalation of rose oil containing 2-Phenylethanol (2mL of 5% 2-Phenylethanol; inhalation; 15min) may be effective against depression and stress-related diseases [6]. In pregnant Long‐Evans rats, noteworthy dose-related teratogenic effects of 2-Phenylethanol (4.3mg/kg, 43mg/kg, 430mg/kg; po; 9d) in offspring manifested themselves in increased incidences of malformed eyes, neural‐tube defects, hydronephrosis, and limb defects [7]. In C57BL/6 mice, 2-Phenylethanol (2mL of 0.08% 2-Phenylethanol; inhalation; 2 hour a day for 7 days) modulates hippocampal endocannabinoid signaling to reduce anxiety-like behavioral defects in mice [8].
References:
[1]. Hua D, Xu P. Recent advances in biotechnological production of 2-phenylethanol. Biotechnology advances. 2011 Nov 1; 29(6): 654-1660.
[2]. Zhu YJ, Zhou HT, Hu YH, et al. Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid. Food Chemistry. 2011 Jan 1; 124(1): 298-302..
[3]. Chreptowicz K, Wielechowska M, Głowczyk-Zubek J, et al. Production of natural 2-phenylethanol: from biotransformation to purified product. Food and Bioproducts Processing. 2016 Oct 1; 100: 275-281.
[4]. Sun S, Tang N, Han K, et al. Effects of 2-phenylethanol on controlling the development of Fusarium graminearum in wheat. Microorganisms. 2023 Dec 10; 11(12): 2954.
[5]. Yin LJ, Wang W, Wang M, et al. 2-Phenylethanol in Endophytes of Areca catechu L. Inhibits the Biofilms and Virulence Against Aeromonas hydrophila. World Journal of Traditional Chinese Medicine. 2025: 10-4103.
[6]. Ueno H, Shimada A, Suemitsu S, et al. Anti-depressive-like effect of 2-phenylethanol inhalation in mice. Biomedicine & pharmacotherapy. 2019 Mar 1; 111: 1499-1506.
[7]. Mankes RF, LeFevre R, Bates H, et al. Effects of various exposure levels of 2‐phenylethanol on fetal development and survival in long‐Evans Rats. Journal of Toxicology and Environmental Health, Part A Current Issues. 1983 Aug 1; 12(2-3): 235-244.
[8]. Bi JR, Zha HW, Gao QL, et al. Pleasant Odor Decreases Mouse Anxiety-like Behaviors by Regulating Hippocampal Endocannabinoid Signaling. International Journal of Molecular Sciences. 2024 Oct 4; 25(19): 10699.
2-Phenylethanol是一种重要的芳香醇，具有类似玫瑰的香气 [1]。2-Phenylethanol具有抗酪氨酸酶和抗菌活性 [2]。2-Phenylethanol用于食品、香料和化妆品行业 [3]。
在禾谷镰刀菌中，2-Phenylethanol（0.6mg/mL、1.2mg/mL、2.4mg/mL；14d）表现出对禾谷镰刀菌菌丝生长的优异抑制作用，EC50值为0.328mg/mL [4]。在嗜水气单胞菌中，2-Phenylethanol（1mg/mL；24h）显著抑制了嗜水气单胞菌生物膜的形成 [5]。
在C57BL/6小鼠中，吸入含有2-Phenylethanol的玫瑰油（2mL 5% 2-Phenylethanol；吸入；15分钟）可能对抑郁症和应激相关疾病有效 [6]。在怀孕的Long-Evans大鼠中，2-Phenylethanol（4.3mg/kg、43 mg/kg、430mg/kg；po；9d）对后代有显著的剂量相关性致畸作用，表现为眼畸形、神经管缺陷、肾积水和肢体缺陷发生率增加 [7]。在C57BL/6小鼠中，2-Phenylethanol（2mL 0.08% 2-Phenylethanol；吸入；每天2小时，持续7天）可调节海马内源性大麻素信号，从而减少小鼠的焦虑样行为缺陷 [8]。