(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.
(±)-Coniine hydrochloride (compound 1) (0.05 mg-0.2 mg; i.v.) shows acute toxicity with an LD50 value of 7.7 mg/kg[1].
References:
[1]. Lee ST, et al. Stereoselective potencies and relative toxicities of coniine enantiomers. Chem Res Toxicol. 2008 Oct;21(10):2061-4.