(±)-Clorprenaline-d7 is intended for use as an internal standard for the quantification of clorprenaline by GC- or LC-MS. Clorprenaline is a β2-adrenergic receptor agonist.1 It reverses pilocarpine-induced constriction of isolated guinea pig trachea, rabbit lung, and bronchi of pithed dogs.2 It has been detected in pork, beef, mutton, and chicken muscle food samples by UPLC-Q-orbitrap-HRMS.1 Formulations containing clorprenaline have been used as partitioning agents and growth promoters in livestock.
1.Guo, C., Shi, F., Gong, L., et al.Ultra-trace analysis of 12 β2-agonists in pork, beef, mutton and chicken by ultrahigh-performance liquid-chromatography-quadrupole-orbitrap tandem mass spectrometryJ. Pharm. Biomed. Anal.107526-534(2015) 2.Powell, C.E., Gibson, W.R., and Swanson, E.E.The pharmacological action of 1-o-chlorophenyl-2-isopropylaminoethanol (isoprophenamine); A bronchodilatorJ. Am. Pharm. Assoc.45(12)785-787(1956)