(±)9-HETE-d8 is intended for use as an internal standard for the quantification of (±)9-HETE by GC- or LC-MS. (±)9-HETE is a monohydroxy fatty acid formed by lipid peroxidation of arachidonic acid , as well as by rat liver microsomal cytochrome P450 (CYP).1,2 Plasma levels of (±)9-HETE are elevated in patients with angiographically defined coronary artery disease.3
1.Powell, W.S., and Rokach, J.Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidBiochim. Biophys. Acta1851(4)340-355(2014) 2.Capdevila, J., Yadagiri, P., Manna, S., et al.Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450Biochem. Biophys. Res. Commun.141(3)1007-1011(1986) 3.Shishehbor, M.H., Zhang, R., Medina, H., et al.Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery diseaseFree Rad. Biol. Med.41(11)1678-1683(2006)