17,20-dimethyl PGF1α is an analog of the limaprost family with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an analog of PGE1 which is orally active in both rats and guinea pigs. The additional methyl groups in the lower side chain confer a 10-1,000 fold increase in potency over the parent compound. 17,20-dimethyl PGF1α has lower side chain modifications identical to limaprost. There are no published reports describing the pharmacology of 17,20-dimethyl PGF1α.
17,20-dimethyl Prostaglandin F1α
目录号: GC41953纯度: >98.00%同义词: 17,20dimethyl PGF1α
An analog of the limaprost family
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥693.00 | 现货 | 1 | |
| 5mg | ¥3,296.00 | 现货 | 1 | |
| 10mg | ¥6,237.00 | 现货 | 1 | |
| 25mg | ¥14,722.00 | 现货 | 1 |
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Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
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Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
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Cell Research33, 904–922 (2023)
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产品描述 Description
产品文档 Product Documents
Purity:>98.00%Appearance:A solid
化学性质Chemical Properties
同义词
17,20dimethyl PGF1α
SMILES
O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H](O)C1
分子式
C22H40O5
分子量
384.6 g/mol
溶解性
DMF: >30 mg/ml (from Limaprost),DMSO: >130 mg/ml (from Limaprost),Ethanol: >50 mg/ml (from Limaprost),PBS pH 7.2: >2 mg/ml (from Limaprost)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol