14-dehydro Zymostenol is a precursor to cholesterol .1 It increases the percentage of myelin basic protein-positive (MBP+) oligodendrocytes formed from oligodendrocyte precursor cells when used at concentrations of 5.8 and 17 µM.2
1.Lutsky, B.N., and Schroepfer, G.J., Jr.Studies on the enzymic conversion of 5α-cholesta-8,14-dien-3β-ol to cholesterolJ. Biol. Chem.245(23)6449-6455(1970) 2.Hubler, Z., Allimuthu, D., Bederman, I., et al.Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelinationNature560(7718)372-376(2018)