11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3]
Reference:
[1]. Dray, F., and Heaulme, M. Prostaglandins of the E series inhibit release of noradrenaline in rat hypothalamus by a mechanism unrelated to classical α2 adrenergic presynaptic inhibition. Neuropharmacology 23, 457-462 (1984).
[2]. Raisz, L.G., and Woodiel, F.N. Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. Prostaglandins 37, 229-235 (1989).
[3]. Itoh, S., Lu, R., Bao, Y., et al. Structural determinants of substrates for the prostaglandin transporter PGT. Molecular Pharmacology 50, 736-742 (1996).
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