GlpBio

10-acetyl Docetaxel

目录号: GC49736纯度: >98.00%同义词: 多西他赛,10-Acetyl docetaxel; PNU-101383
A derivative of paclitaxel and an inhibitor of microtubule depolymerization
10-acetyl Docetaxel
Cas No.: 125354-16-7
规格价格库存数量操作
50mg¥927.00现货
1
100mg¥1,545.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

10-acetyl Docetaxel is a derivative of paclitaxel and an inhibitor of microtubule depolymerization.1 It inhibits calcium-induced depolymerization of calf brain microtubule protein (MTP) in a cell-free assay when used at 20 µM. 10-acetyl Docetaxel is cytotoxic to J774.2 cells (EC50 = 0.05 µM).

1.Swindell, C.S., Heerding, J.M., Krauss, N.E., et al.Characterization of the taxol structure-activity profile for the locus of the A-ring side chainBioorg. Med. Chem. Lett.4(12)1531-1536(1994)

产品文档 Product Documents

Purity:>98.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
125354-16-7
同义词
多西他赛,10-Acetyl docetaxel; PNU-101383
SMILES
C[C@]1(C([C@@H](C2=C(C)[C@@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C3=CC=CC=C3)=O)C[C@]4(O)C2(C)C)OC(C)=O)=O)[C@@]([C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]([C@@]6([H])C[C@@H]1O)(CO6)OC(C)=O
分子式
C45H55NO15
分子量
849.9 g/mol
溶解性
DMF: 2 mg/ml,DMSO: 3 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): insol
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol